England lead the five-ODI series versus West Indies 1-0 after win in the first ODI.
England and West Indies second one-day international was abandoned after only 2.2 overs at Trent Bridge.
Jonny Bairstow scores maiden ODI century and Stokes took three for 43 ensured West Indies suffered a seven-wicket defeat at Old Trafford on Tuesday.
Visitors need to win the five-match ODI series by a margin of 5-0 or 4-0 for direct qualification for the 2019 global event.
Duo picked up six English batsmen as visitors defended 176 to win the one-off T20I after Gayle and Lewis set the agenda.
Ireland - West Indies one-off ODI at Stormont is abandoned after rain at lunchtime finally puts paid to hopes of any play.