Chanderpaul debut knock lifts West Indies after Labuschagne, Smith flay double hundreds.
At the end of the end of first day play, Labuschagne (154*) and Smith (59*) stood tall for Australia.
The result ensured Irish qualification for the Super 12 round of the T20 World Cup.
Alzarri Joseph returned four wickets, while Jason Holder bagged three.
All-round Scotland cause massive upset, defeat West Indies by 42 runs.
South Africa will complete their 2023 ODI World Cup qualification cycle with five matches at home early in 2023, against England and Netherlands.