Ishant Sharma, Umesh Yadav and Kuldeep Yadav pick three each as India take big lead.
India finished first day on 297 for 5 after Windies dent early blow.
Virat Kohli scores 43rd ODI century helps India clinch 2-0 series win against Windies.
Lewis, Pooran flickered briefly for West Indies, but a flurry of wickets in the middle overs derailed the hosts.
Deepak Chahar, Rishabh Pant and Virat KOhli shine as India complete Windies whitewash.
India beat West Indies by 22 runs (D/L method) in the second T20I in Lauderhill, Florida on Sunday.